Karen Christman wins competitive NIH Transformative research grant

​CEN PI Karen Christman and Prof. Gianneschi’s proposal was one of only 20 to be funded from among thousands of applications. With this award, the team will develop nanoparticles that form a scaffold upon activation by proteases present in infarcted tissue. The scaffold stabilize the ventricle wall and prevent negative remodeling, as seen with previously developed injectable scaffolds. This nanomedicine-based approach will enable much earlier treatment than is currently possible, since nanoparticles can be delivered intravenously rather than via catheter into the heart itself, which is only safe at least a week after a heart attack.

The Transformative Initiative, part of the NIH Common Fund’s high-risk high-reward program, advances interdisciplinary research likely to fundamentally change understanding or treatment of disease.