Uhrich and Moghe’s breakthrough stemmed from their recognition that the low efficacy of small molecule blockers of the oxidized LDL receptor likely resulted from the fact that the receptor is...
Most drug-carrying nanoparticles are created by mixing drugs with lipids or polymers in complex mixtures of organic and aqueous solutions to create nanostructures (vesicles or polymer networks)...
Polymers without inherent molecular recognition abilities selectively recognize small molecules when adsorbed to carbon nanotubes.
Biomimetic strategy enables most effective nanoparticle formulation for oral delivery of insulin to date.
Major advance in tumor-specific pH-activated fluorescent imaging by Jinming Gao's group in Nature Materials.
New capabilities for a cutting-edge in vivo imaging method: activatable photoacoustic contrast agent
In a research field-hopping advance, Jianghong Rao's lab finds that semiconducting polymer nanoparticles yield greater photoacoustic imaging contrast than previously studied materials.
Novel strategy incorporating a biocompatible metal catalyst promises tumor-specific activation of 5-fluorouracil.
Combining light-responsive proteins with transplantation of stem cell-derived neurons overcomes the challenges of each approach.
Hypoxia can be detected up to one month after injection of a depot MRI agent, which could inform cancer treatment decisions.
Albumin nanoparticles may selectively target neutrophils, which could lead to novel anti-inflammatory therapies.
Polymeric nanoparticles coated with activated platelet-binding peptides developed previously by Erin Lavik's lab show promise for treating combat and accident injuries.
Sonic vibrations can induce cells to form complex patterns, which could be useful in creating engineered tissues.
Local delivery of a viral vector containing a transcription factor gene induces temporary endogenous pacemaker function in pigs.
New screening method could identify the first disease-modifying drugs for multiple sclerosis.
While not exactly brain-like, the David Kaplan group's 3D neuronal culture system represents an important advance because its mechanical stability supports long-term survival.